MOTS-c is a 16–amino acid peptide encoded by mitochondrial DNA that has been studied for its role in cellular and metabolic signaling pathways. Research has examined its interaction with AMP-activated protein kinase (AMPK), a key regulator involved in energy balance and metabolic regulation. Experimental studies have explored associations between MOTS-c activity and pathways related to fatty acid metabolism, gluconeogenic signaling, and glucose homeostasis within controlled models.
Additional research has investigated MOTS-c in the context of cellular stress response pathways, including its involvement in mechanisms related to stress adaptation and resilience at the cellular level. Studies have also examined its relationship to inflammatory signaling and oxidative stress markers in preclinical and laboratory settings.
Emerging research suggests that MOTS-c may participate in mitochondrial–nuclear communication, with investigations exploring its ability to interact with nuclear transcriptional regulators and influence gene expression under specific experimental conditions.
This peptide is supplied as a lyophilized powder to support stability for laboratory and research use.





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